JILTI. 2023; 1(3): 113-116 | DOI: 10.14744/jilti.2023.50479

Varicella Zoster Fulminant Hepatitis in a Pediatric Patient with Leukemia: Recovery Without Liver Transplantation

Fatma İlknur Varol¹, Arzu Akyay², Kamuran Karaman³, Nese Karadag^4
1Department of Pediatric Gastroenterology and Hepatology, Inonu University Faculty of Medicine, Malatya, Turkiye
²Department of Pediatric Hematology and Oncology, Inonu University Faculty of Medicine, Malatya, Turkiye
³Department of Pediatric Hematology and Oncology, Yuzuncu Yil University, Van, Turkiye
⁴Department of Pathology, Inonu University Faculty of Medicine, Malatya, Turkiye

Acute liver failure is a sudden and rapidly developing acute liver injury, with impaired metabolic-synthetic function of the liver, with or without encephalopathy that causes multi organ failure in a healthy person. Acute liver failure can develop due to many different reasons. In this report, we presented a child patient who received chemotherapy with the diagnosis of acute lymphoblastic leukemia and developed acute liver failure after Varicella-Zoster Virus infection.In this patient, liver transplantation could not be performed due to active viral infection, and she improved after acyclovir and supportive care with plasmapheresis. To the best of our knowledge, this is the only immunosuppressed child patient in the literature who improved from acute liver failure after Varicella-Zoster Virus infection without liver transplantation.

Keywords: Varicella-Zoster Virus, acute lymphoblastic leukemia, acute liver failure, plasmapheresis.

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