Integration of Comprehensive Genomic Profiling into Clinical Settings for Gastrointestinal System Cancer Enhancing Diagnosis, Molecular Classification, and Therapeutic Precision

The advent of comprehensive genomic profiling (CGP) has revolutionized cancer diagnosis and personalized treatment and has become increasingly standard in oncology for advanced solid tumors. In gastrointestinal (GI) cancers, which include colorectal, gastric, pancreatic, esophageal, biliary tract cancers, and hepatocellular carcinomas, genomic insights have increasingly informed clinical decision-making. This review provides an overview of the current landscape of CGP integration into clinical practice for GI cancers, highlighting clinical applications, challenges, and future perspectives.

Keywords: Comprehensive genomic profiling, gastrointestinal cancers, liquid biopsy, molecular classification, precision medicine, targeted therapy